Guile is a video game character in Capcom's Street Fighter series of fighting games. Although his role in the Street Fighter story is minimal, he is considered the third leading male character in the series, after Ryu and ken Masters, largely due to his effectiveness as a character and his popularity.
When Guile was a Lieutenant in the United States Air Force, he befriended his superior officer, Charlie Nash and asked him to teach him in his unique form of fighting, which Charlie agreed to do. Guile learned the style, but his hot temper caused him to be not as proficient in the moves as Charlie was (shown in how Charlie can shoot Sonic Booms with just one hand while Guile needs both.)
Guile has a wife, Julia, and daughter, Chris (known as Amy internationally). Also, Julia and Eliza Masters are actually sisters, making Ken and Guile brothers-in-law. However, this is not often discussed because, despite mutual respect as fighters, they do not think very highly of one another — Guile believes Ken to be a spoiled rich kid; Ken feels Guile is just another meathead soldier. In Street Fighter IV, if Ken beats Guile, he'll refer to him as his "brother-in-law".
There's a running gag about his theme music from Street Fighter II "fitting in" or "going with" every scene or moment imaginable. Also, a neta called Waiting Guile (待ちガイル) refers to the strategy wherein the player crouches in the corner waiting for the opponent to approach, only to then hit them with either one of his charge moves.
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