Samus would cut a swath of destruction through a xenomorph nest.

the more i play metroid dread the more i want to see this fight

Ridley's basically a giant Xenomorph with wings, and she's killed him a comical number of times. Normal sized ones would barely slow her down.

Ellen Ripley was the inspiration for Samus, so fitting.

NegativeSoul said:

Samus would cut a swath of destruction through a xenomorph nest.

It would probably be more of a long-range destruction, considering the acid blood